The week’s most important critical care research.

MicroRNAs and Precision Medicine in Acute Respiratory Distress Syndrome: Moving beyond Clinical Phenotypes

Rustagi A, Wiener-Kronish J, Pirracchio R

ARDS at 60: beyond lung protection to lung repair

Phenotyping ARDS: A pragmatic path forward with the POLARIS international cohort

Association between baseline mean perfusion pressure and mortality in ARDS may depend on age

Gkirgkiris K, Konstantinou G, Papoutsi E et al.

Cyclosporine treatment of ARDS due to severe COVID-19: The I-SPY COVID Adaptive Platform Trial

Haczku A, Moskowitz A, Eklund M et al.

Association of Acute Respiratory Distress Syndrome Radiographic Findings Identified by Machine Learning and Outcomes of Patients Receiving Invasive Mechanical Ventilation

Zhong Y, Nuppnau M, Farzaneh N et al.

Hierarchical ventilator-free days with win method in acute respiratory distress syndrome treatment

Zhou, Y., Ma, J., Chen, H., Wu, Z., Liu, L., Chen, T.

WHAT IS ALREADY KNOWN ON THIS TOPICThe composite endpoint ventilator-free days (VFDs) was developed to incorporate both survival and liberation from mechanical ventilation, yet its interpretation and analysis remain methodologically challenging. WHAT…

Air pollution and chronic obstructive pulmonary disease: beyond respiratory outcomes

Badri, H., McFiggans, G., Voliotis, A.

For many patients with chronic obstructive pulmonary disease (COPD), the greatest threat to survival may arise not from respiratory failure but from cardiovascular disease. COPD is increasingly recognised as a systemic disease…

Hierarchical composites and the promise of the win ratio in ARDS trials

Taran, S., Zampieri, F.

Composite outcomes capture multiple effects of an intervention and are widely used in clinical trials.1 By combining different events of interest, composites increase the overall event rate of a trial and require…

Prone positioning redirects exhaled aerosol and changes bedside staff exposure during respiratory support

Ketamine as an Opioid-Sparing Adjunct During Mechanical Ventilation: Feasible and Ready for a Larger Trial

Prendergast NT, Girard TD

Music Therapy During Weaning From Invasive Mechanical Ventilation in the ICU: A Randomized Controlled Trial

Pereiro S, Corral E, Del Campo P et al.

Diagnostic Performance of the Radiographic Assessment of Lung Edema Score for Acute Respiratory Distress Syndrome-Post Hoc Analysis of the "Validating Acute Lung Injury Biomarkers for Diagnosis" Study

Zimatore C, Jabaudon M, Pisani L et al.

Eligibility for Early Mobilization in Mechanically Ventilated Adults: A Multicenter Study

Patel BK, Chhikara K, Jain S et al.

Assessment of Tidal Volume in Patients Undergoing Noninvasive Ventilation: Systematic Review and Meta-Analysis

Santa Cruz R, Matesa A, Jara M et al.

Should the esophageal balloon catheter be deployed to personalize ventilation of ARDS? Authors’ reply

The pulmonary circulation in ARDS: from pathophysiology to clinical applications

Sputum cellularity and health services utilization among patients with asthma and COPD

Nair P, Zhang K, Lauks S et al.

Corrigendum to: Transpulmonary Driving Pressure, End-Expiratory Transpulmonary Pressure, and Mortality in Pediatric ARDS

Airway Secretions During Mechanical Ventilation: What We See, What We Measure, and What We Still Do Not Know

Ntoumenopoulos G

Agreement Between Automated and Equation-Derived Mechanical Power in Pediatric Mechanical Ventilation

Shaikh FAR, Bhaskaran MK, Muppa V et al.

Development and Validation of the Respiratory Secretion Scale (RESES) in Mechanically Ventilated Patients

Ferrari G, Magnante J, Mantelli LM et al.

In Vitro Study of Nebulizer Position Effects on Colistimethate Sodium Administration, Drug Deposition, and Filter Pressure Drop in Mechanical Ventilation

Wu MF, Hsieh MJ, Wu YC et al.

Machine Learning‒Based Predictors of Prolonged Mechanical Ventilation Duration Following Coronary Artery Bypass Grafting

Chen S, Qin Y, Feng D et al.