From The Newsletter
Every Substack post, organised by ICCN's ten editorial tracks. Two new editions every weekday — a 06:00 ET flagship and a 12:00 ET brief — concise, evidence-based, built for the bedside.
Tuesday 06:00 ET · Mechanical Ventilation
October 27, 2026
A PROSEVA reanalysis asked whether lung stiffness or the drop in driving pressure after turning identifies who benefits. In this analysis, neither did.
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Monday 12:00 ET · Infectious Disease
October 26, 2026
Twenty years of national surveys show external catheters surging while catheter reminders slipped, even though the reminders carry the stronger evidence
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Monday 06:00 ET · Sepsis & Shock
October 26, 2026
In nearly seven hundred septic adults, more than one in four developed acute kidney disease, and a creatinine trend matched newer biomarkers at predicting it.
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Friday 12:00 ET · AI in Healthcare
October 23, 2026
A reasoning model agreed with Cochrane reviewers on about three in four bias calls. Where it slipped, and how to keep humans in charge.
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Friday 06:00 ET · Neuro & Recovery
October 23, 2026
Across 654,660 Swiss ICU stays, women more often had treatment limits documented at admission. What the timing reveals about goals-of-care conversations.
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Thursday 12:00 ET · Research & Evidence Mastery
October 22, 2026
A Swiss cluster trial of ICU family nurses shows why randomizing units changes the math, and who ends up enrolled
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Thursday 06:00 ET · Pharmacology & Nutrition
October 22, 2026
Continuous piperacillin reached its target in about one patient in three on the first level. Kidney function largely decided who ran low or high.
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Wednesday 12:00 ET · ECMO & Extracorporeal Support
October 21, 2026
A Paris cohort asks what happens when adults leave venovenous ECMO with acceptable gas exchange but injurious lung mechanics on the sweep-off trial.
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Wednesday 06:00 ET · Cardiac & Hemodynamics
October 21, 2026
A Bayesian reanalysis of MINT puts a probability on the transfusion question a borderline result left open for anemic patients after infarction.
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Tuesday 12:00 ET · Airway, Liberation & Recovery
October 20, 2026
A German network brought specialist respiratory therapists and pulmonologists to high-risk patients in general ICUs. The signal is promising, imprecise, and demanding to build.
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Tuesday 06:00 ET · Mechanical Ventilation
October 20, 2026
A sepsis cohort tests the pulse oximetry ratio inside the Global ARDS definition, and shows where it earns trust and where it overcalls
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Monday 12:00 ET · Infectious Disease
October 19, 2026
A randomized ICU trial found MRSA nasal PCR highly reliable at ruling out MRSA, but could not show shorter vancomycin courses. Stewardship may explain why.
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Monday 06:00 ET · Sepsis & Shock
October 19, 2026
Across nearly thirty thousand Michigan sepsis admissions, vomiting and diarrhea went with slower antibiotics, and a fever reported at home with faster ones.
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Friday 12:00 ET · AI in Healthcare
October 16, 2026
Outcomes looked better when bedside settings happened to match a new AI ventilator coach. How to read that claim before it reaches your unit.
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Friday 06:00 ET · Neuro & Recovery
October 16, 2026
The first Australian randomized trial of the ABCDEF bundle did not reduce delirium. What it reveals about dose, fidelity, and the questions families ask.
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Thursday 12:00 ET · Research & Evidence Mastery
October 15, 2026
A positive sivelestat trial teaches the comparison readers skip: the absolute difference, set by how often the control arm got sick
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Thursday 06:00 ET · Pharmacology & Nutrition
October 15, 2026
A double-blind trial in prolonged ventilation found equation-based feeding overshot measured needs, and could not prove that measuring them speeds weaning
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Wednesday 12:00 ET · ECMO & Extracorporeal Support
October 14, 2026
WEANILEVO gave levosimendan to VA-ECMO patients ready to wean. Weaning failure did not move, kidney injury was more common, and mortality remains unsettled.
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Wednesday 06:00 ET · Cardiac & Hemodynamics
October 14, 2026
A BOX trial substudy in post-arrest cardiogenic shock: chasing a higher pressure with norepinephrine raised cardiac output and wedge pressure, not survival.
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Tuesday 12:00 ET · Airway, Liberation & Recovery
October 13, 2026
A randomized trial of armchair versus bed positioning in patients on respiratory support, and what it asks of the whole team
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The Friday 12:00 ET AI in Healthcare brief is free in full. Members get the full archive and all ten tracks.