The week’s most important critical care research.

Correction to: Effectiveness of Nurse-Coordinated, Digital-Supported Collaborative Care Model in Reducing Hospital Stay and Mortality Among Patients With Heart Failure: TIME-HF Cluster RCT India

Jeemon P, Ganapathi S, Anikkady N et al.

Correction to: Mechanosensitive Endothelial METTL7A Regulates Internal m(7)G mRNA Methylation and Protects Against Atherosclerosis

Shentu TP, Wu T, Zhou Z et al.

Effect of Activin Type II Receptor Signaling in Patients With HFpEF and Pulmonary Hypertension: A Critical Analysis of Biological Mechanisms and Clinical Trials

Packer M, Gomberg-Maitland M, Tedford RJ et al.

Price Variation in Outpatient Percutaneous Coronary Intervention

Reddy KP, Murali N, Smith NK et al.

Letter by Deng and Chen Regarding Article, "Breast Cancer Reveals Latent BMPR2-Related Susceptibility to Pulmonary Hypertension"

Deng W, Chen Y

Letter by Shui et al Regarding Article, "Breast Cancer Reveals Latent BMPR2-Related Susceptibility to Pulmonary Hypertension"

Shui W, Chen Z, Lan C

Care Pathways to Support People Living With Heart Failure

Kuehn BM

Response by Mougin et al to Letter Regarding Article, "Breast Cancer Reveals Latent BMPR2-Related Susceptibility to Pulmonary Hypertension"

Mougin M, Jambon-Barbara C, Boucherat O et al.

Letter by Yuan et al Regarding Article, "Breast Cancer Reveals Latent BMPR2-Related Susceptibility to Pulmonary Hypertension"

Yuan X, Pan K, He S

Optimizing US Prehospital Care of ST-Segment-Elevation Myocardial Infarction Because Time Is Life, Not Just Muscle

Coller BS, Mehran R

Cardiac Allograft Vasculopathy Demonstrated by Coronary Angiography and Histopathological Correlates

Jonas E, Stitziel NO, Hyacinth S et al.

Correction to: Development and Validation of the American Heart Association's PREVENT Equations

Khan SS, Matsushita K, Sang Y et al.

Natural Missplicing Events Amplified by an Elusive Deep-Intronic MYBPC3 Variant Cause Hypertrophic Cardiomyopathy

Gallego-Delgado M, Lorenzo Hernández SM, García Hernández S et al.

Correlation Between EMS Agency Rates of Survival to Hospital Admission and Hospital Survival Outcomes for Cardiac Arrest

Attachaipanich T, Girotra S, Kennedy KF et al.

LDLR Variant Classification Through Activity-Normalized Prime Editing Screening

Zhou PJ, Velimirovic M, Yu T et al.

Multimodal Collaborative Care for Heart Failure in Resource-Limited Settings

Gupta R

Advancing the Science of Nurse-Led Collaborative Care in Heart Failure

Kitko L

Effectiveness of Nurse-Coordinated, Digital-Supported Collaborative Care Model in Reducing Hospital Stay and Mortality Among Patients With Heart Failure: TIME-HF Cluster RCT (India)

Jeemon P, Ganapathi S, Anikkady N et al.

Coronary Artery Calcium (CAC): From Marker to Treatment Target?

Lauer MS

Cholecalciferol and Menaquinone Supplementation: Does Prevention of Coronary Artery Calcium Progression Mean Heart Benefit?

Davis JW, Manson JE

Urgent, Emergency, and Salvage Transcatheter Aortic Valve Implantation for Acute Decompensated Severe Aortic Stenosis: A Prospective Cohort Study

Zhao M, Wang J, Gao L et al.

Therapeutic Targeting of the Macrophage YTHDC1/TIGAR/NF-κB Axis Mitigates Pulmonary Hypertension

Wang J, Feng Y, Shen Y et al.

Defining three coagulation-based phenotypes for OHCA patients undergoing ECPR: an unsupervised cluster analysis

Scquizzato T, Fominskiy E, Calabrò MG et al.

Extracorporeal cardiopulmonary resuscitation strategies for refractory out-of-hospital cardiac arrest

Background Methods Results Conclusions

Earlier Versus Later Extracorporeal Cardiopulmonary Resuscitation in Refractory Out-of-Hospital Cardiac Arrest: A Nationwide Sequential Landmark Target Trial Emulation

Sim JH, Park B, Lee H

[Obituary] Khairul Islam

Jacqui Thornton

Public health doctor and sanitation pioneer. Born on June 25, 1959, in Tangail, in what is now Bangladesh, he died from a cardiac arrest in Dhaka, Bangladesh, on Aug 21, 2026, aged…

GDF-15 as an early marker for prognosis in patients with out-of-hospital cardiac arrest - Experience from the HAnnover COoling REgistry

Akin M, Garcheva V, Sanchez Martinez C et al.

Comparative Analysis of Tracheal Intubation-Associated Cardiac Arrest in 2015-2023: A Report From the National Emergency Airway Registry for Children Multicenter Registry

Padiyath A, Padiyath F, Berg RA et al.

Beyond Bubble Wrap for the Heart: Gas Exchange and Respiratory Support in Cardiogenic Shock

Siuba MT

Modulating metabolism to mitigate reperfusion injury induced by resuscitation from cardiac arrest: a narrative review

Graphical Abstract

Reply: Trajectory-Based Myocardial Remodeling and MACE Risk in Phenotypically Mild HCM

Topriceanu CC, Ho CY, SHaRe investigators

Temporal Alignment of Remodeling Trajectories in Mild HCM

Rawashdeh BMM, Muhaisen AHM

From Risk Trajectories to Surrogate Endpoints in Mild HCM

Zhou X, Liu H, Hua Z

Atrial Cardiomyopathy in Hypertrophic Cardiomyopathy: From Compensation to Atrial Fibrillation

Chan RH, Rakowski H

What We Lose When the Threshold Becomes the Answer

Krumholz HM

Physiological Left Atrial Staging and the Risk of New-Onset Atrial Fibrillation in Hypertrophic Cardiomyopathy

Lim J, Hwang IC, Kim J et al.

Beyond the 15-mm Threshold: Toward Personalized Assessment of Left Ventricular Hypertrophy in Hypertrophic Cardiomyopathy

Abdelfattah OM, Nagueh SF, Martinez MW

Surgical Myectomy for Symptomatic Obstructive Hypertrophic Cardiomyopathy: Still Highly Relevant (and Innovating) After 65 Years

Maron BJ, Maron MS

Hypertrophic Cardiomyopathy: Entering a Novel Pharmacologic Era…But Is Now Also a Low Mortality Disease With Longevity

Maron BJ

Clinical Considerations in Management of Hypertrophic Cardiomyopathy in Pregnancy: JACC State-of-the-Art Review

Abdelfattah OM, Abdeldayem J, Hassan AA et al.

Natural History of Asymptomatic Phenotypically Mild HCM: Insights From the SHaRe Registry

Topriceanu CC, Balakrishnan ID, Vissing CR et al.

Preparing for Tomorrow, Today: Identifying Predictors of Future Cardiac Complications in Patients With Mild Hypertrophic Cardiomyopathy

Russell MW, Meisner JK

Long-Term Outcome of Myectomy Associated With Secondary Mitral Valve Chordal Cutting in Obstructive Hypertrophic Cardiomyopathy

Ferrazzi P, Spirito P, Binaco I et al.

Mavacamten in Nonobstructive Hypertrophic Cardiomyopathy: Baseline Characteristics, Drug Exposure, and Outcomes in an Exploratory Analysis From ODYSSEY-HCM

Desai MY, Owens A, Garcia-Pavia P et al.

Midventricular Obstruction in Hypertrophic Cardiomyopathy: Clinical Outcomes in a Multicenter Cohort

Schulz A, Rowin EJ, Peng LW et al.

Inflammation in cardiogenic shock: a marker of outcome, not yet a treatment target

Guzik TJ

Exercise Prescriptions for Cardiovascular Health in Adults: 2026 ACC Scientific Statement: A Report of the American College of Cardiology

Myers J, Beckie TM, Chastin S et al.

Making Sarcopenic Obesity Actionable for Heart Failure Prevention

Zhou X, Liu H, Hua Z

Is the Sarcopenic Obesity Index a Pathophysiological Phenotype or Merely a Ratio?

Chen T, Liu Y, Wu D

Home Sweet Home: Redefining the Destination of Heart Failure Care

Gilotra NA, Ditlevson M

Early Discharge Strategy Including Subcutaneous Furosemide in Hospitalized Heart Failure

Campbell RT, Osmanska J, Docherty KF et al.

Reply to: Did prolonged high-level pump support precede acute kidney injury?

Nakashima T, Unoki T, Tsujita K

Early Rehabilitation After High-Risk Cardiac Surgery: A Practical Proceed-Modify-Hold Framework

Piwoda A, Batycka-Stachnik D, Sobczyk D

Prognostic implications of complications during VA-ECMO for cardiogenic shock

Rali AS, Sarma D, Li H et al.

Sotatercept in Pediatric Pulmonary Hypertension: Experience from the Pediatric Pulmonary Hypertension Network

Critser PJ, Krishnan US, Avitabile CM et al.

Answer: Acute chest pain in Duchenne muscular dystrophy

Dias M, Mané F, Files Flores R

We didn't start the fire1

Vranckx P, Morrow D, van Diepen S et al.

Inflammation, Infarct Size and 10-Year Mortality in STEMI Patients Stratified by the ORBI Risk Score: A DANAMI-3 Sub-study

Kunkel JB, Lønborg J, Frydland M et al.

A Puzzling Left-to-Right Flow After Transcatheter Atrial Septal Defect Closure in a Child

Maddali MM, Al-Maskari SN, Elshemy AM et al.

Autologous Platelet-Rich Plasma Decreases Intraoperative Allogeneic Transfusion in Cyanotic Patients Undergoing Cardiac Surgery

Li H, Li H