The week’s most important critical care research.

Adolescent Cardiorespiratory Fitness and the Trade-Off Between Atrial Fibrillation Risk and Cardiovascular Benefits: A Nationwide Sibling-Controlled Cohort Study

Ballin M, Carlsson AC, Wändell P et al.

Cardiac Intensive Care Unit Appropriate Patient Selection and Triage: A Scientific Statement From the American Heart Association

van Diepen S, Rampersad P, Luk A et al.

Observational Comparative Research in Cardiovascular and Brain Health and Disease: A Scientific Statement From the American Heart Association

Mac Grory B, Yeh RW, Beckman JA et al.

An Unfinished ANTHEM: Ethics, Evidence, and Early Trial Termination

Kadakia KT, Dhruva SS

Vagal Nerve Stimulation in Patients With Heart Failure and Reduced Ejection Fraction: The ANTHEM-HFrEF Trial

Konstam MA, Udelson JE, Mann DL et al.

Sex and Age Specific Genetic Risk Across the Dilated and Arrhythmogenic Cardiomyopathy Spectrum: Insights From the SHaRe Registry

Stroeks SLVM, Bart NK, Rossano J et al.

Left Ventricular Unloading in STEMI: From Bench to Bedside and Back Again

Møller JE, Holmvang L, Yeh R et al.

Improving Cardiology Care Within Constrained and Distinctive Health Care Systems

Wasfy JH

When Trials Stop Prematurely: Transparency, Governance, and Our Responsibility to Patients

Krumholz HM

Chronic PM(2.5) Exposure Is Associated With Invasively Assessed Coronary Endothelial Dysfunction

Manzato M, Kalhor P, Nogami K et al.

Charting New Territories in Cardiac Care Intensive Care Rehabilitation and the Enduring Impact on Post-Acute Cardiac Event Outcomes

Thompson AD, Nguyen K, Alhuneafat L et al.

Inflammation and endothelium after cardiac arrest: a complex relationship

Benghanem S, Bois A, Cariou A

Evolocumab in Patients With Prior Percutaneous Coronary Intervention and No Prior MI: Results From the VESALIUS-CV Trial

Bergmark BA, Bohula EA, Marston NA et al.

Multidimensional Social Adversity and Mortality in People With HIV Infection and Heart Failure: Insights from NYC Health + Hospitals HIV-Heart Failure Cohort

Chen YY, Borkowski P, Biavati L et al.

Evaluating Cardiovascular Devices Using Observational Analyses

Lalani C, Dahabreh IJ, Cohen DJ et al.

Cas13-Mediated RNA Base Editing for the Treatment of Hereditary Hypertrophic Cardiomyopathy

Hu Q, Lin J, Cui H et al.

Targeting Lymph Node Entry to Improve Cardiac Graft Tolerance

Georgiopoulos G, Tseliou E, Kallikourdis M

Highlights From the Circulation Family of Journals

Response by Chen and Duan to Letter Regarding Article, "Oral Pathobionts Aggravate Myocardial Infarction Through Mobilization of B2 Cells"

Chen BY, Duan SZ

Letter by Pan and Ding Regarding Article, "Oral Pathobionts Aggravate Myocardial Infarction Through Mobilization of B2 Cells"

Pan Y, Ding J

Incretin-Based Therapies and Cardiovascular Outcomes: Beyond Weight Loss

Després JP, Neeland IJ

Effect of APOC3 Inhibition With Olezarsen on Coronary Atherosclerosis: Essence-TIMI 73b Imaging Study

Marston NA, Bergmark BA, Prohaska TA et al.

A New Dawn for Pre-Hospital Heparin in STEMI? Insights From the HEPARIN STEMI Trial

Gorog DA, Landi A

Prehospital Heparin Administration in Patients With STEMI Undergoing Primary PCI: HEPARIN-STEMI Randomized Controlled Trial

Fister M, Noc M, Radsel P et al.

HEV-Targeted Antibody-Drug Conjugate Promotes Long-Term Cardiac Allograft Acceptance

Che Y, Yamamura Y, Jung S et al.

Lipid-Lowering Therapy in the 2026 ACC/AHA/Multisociety Guideline on the Management of Dyslipidemia: A Perspective From China

Li JJ

A Hispanic/Latino Perspective on the 2026 American College of Cardiology/American Heart Association Guideline for the Management of Dyslipidemia

Duran-Luciano P, Montanez-Valverde R, Slipczuk L et al.

Relevance of the U.S. Dyslipidemia Guideline to Low- and Middle-Income Countries

Noubiap JJ, Huffman MD, Ntsekhe M

Improving Primary Prevention in South Asians: A Regional Perspective for the 2026 Dyslipidemia Guidelines

Kanaya AM, Shah NS, Prabhakaran D et al.

Building Global Bridges in Clinical Guidance: Harmony Across Dyslipidemia Guidelines

Tiosano S, Morris PB, Koskinas KC et al.

Expansion of the Guideline-Recommended Role for Coronary Artery Calcium: Initiation and Intensification of Lipid-Lowering Therapy

Blaha MJ

Translating the 2026 Dyslipidemia Guideline for Impact: The Science Needed for Implementing the PREVENT Equations

Khan SS, Beidas RS

Triglycerides and Residual Risk, Where Do They Fit Now?

Nordestgaard BG

Dyslipidemia in Older Adults: Balancing Prevention and Individualized Care

Nanna MG, Rossi R, Anderson TS et al.

Putting the 2026 Dyslipidemia Guideline Into Action in Primary Care: Implementation Challenges and Opportunities

Sterling MR, Spatz ES

Primary Prevention for People Living With HIV: A Call to Action

Zanni MV, Lu MT, Chu SM et al.

Dyslipidemia in Women: Reproductive Factors and Risk Across the Life Course: Advances in the 2026 ACC/AHA/Multisociety Dyslipidemia Guideline

Michos ED, Blumenthal RS

New Dyslipidemia Guideline Expands Treatment Options and Risk Assessment in Patients With Diabetes and Chronic Kidney Disease

Saseen JJ, Soffer DE, Wilkins JT

Measuring What Matters: Understanding Recovery, Function, and Life Beyond Survival After CICU Discharge

Sterling LH, Mathew R, Parlow S

All creatures are equal: yet some are more reported than others

Vranckx P, Morrow D, van Diepen S et al.

Answer: An unexpected culprit in acute chest pain

Siever M, Teng LE

Question: An unexpected culprit in acute chest pain

Siever M, Teng LE

Long-term outcomes after acute coronary syndromes in trials under-represented by women: do we only see what we want to see?

Mehran R, Rubini Gimenez M

Impact of right heart failure in patients with cardiogenic shock

Lapetina Arroyo R, Khosla P, Caraballo C et al.

**Response to ACC-D_25-00707: on the cardiac tamponade scoring system in the 2025 ESC guidelines*

Impact of female underrepresentation in trials investigating long-term pharmacologic therapy after acute coronary syndrome: a meta-analysis and meta-regression

van der Bijl MF, Paulis LA, den Ruijter HM et al.

Guided de-escalation of antiplatelet treatment in patients at high atherothrombotic risk presenting with acute coronary syndrome: a post hoc analysis of the TROPICAL-ACS trial

Farhan S, Hein R, Trenk D et al.

Young adults in the cardiac intensive care unit: insights from the Critical Care Cardiology Trials Network registry

Isath A, Sharma T, Mahmood U et al.

High LDL cholesterol confers greater risk of ST-segment elevation myocardial infarction than non-ST-segment elevation myocardial infarction in statin-treated patients with ischaemic heart disease

Hansen MK, Mortensen MB, Olesen KKW et al.

Views on the approach algorithm and scoring for 'definite cardiac tamponade' in the 2025 ESC guidelines for myocarditis and pericarditis

Nural A, Savaş G

Why do guidelines ignore the management of type 2 myocardial infarction?

White HD

Resuscitation From Out-of-Hospital Cardiac Arrest When Is EtCO(2) Reliably Associated With ROSC?

Nassal MMJ, Smith RM, Aramendi E et al.

Comparative Efficacy of Transfusion Strategies in Women and Men With Myocardial Infarction and Anemia: Prespecified Secondary Findings From the MINT Trial

Abbott JD, Benatar JR, Ballantyne CM et al.

Laroprovstat, the First Oral Small-Molecule PCSK9 Inhibitor for the Treatment of Hypercholesterolemia: Results From a Randomized, Single-Blind, Placebo-Controlled Phase 1 Trial in Treatment-Naive Patients

Vega RB, O'Mahony G, Barbour AM et al.

Reply to "Letter to the Editor: To stent, shock, or stand-by? : Post-partum spontaneous coronary artery dissection with ventricular fibrillation"

Kidambi BR, Seemala SK, Gilhooley S et al.

Cardiopulmonary Interactions During Positive Pressure Ventilation: A Clinico-Physiological Framework

Alviar CL, Tavazzi G

Secondary Prevention After Coronary Artery Bypass Graft Surgery: 2026 Update: A Scientific Statement From the American Heart Association

Ruel M, Sandner S, Ponnambalam M et al.

Automated Impella Controller Overestimates Device Flow: Direct Measurement in a Mock Circulatory Loop

Said CF, Hayward C, Jain P

Letter to the Editor: Postpartum SCAD: Stand-by

Caunite L, Montero-Cabezas JM

The Impact of Blood Pressure Targets on Hemodynamics in Patients With Cardiogenic shock Caused by Infarction-Related Out-of-Hospital Cardiac Arrest: A Substudy of the BOX-trial

Ten Berg S, Beske RP, Grand J et al.