The week’s most important critical care research.

Evaluation of Activated Clotting Time Response to Unfractionated Heparin in Vascular Surgery: An Observational Study

Garberi R, Milan M, Palermo R et al.

Corrigendum to 'Comparison of Propofol-Based Total Intravenous Anesthesia versus Volatile Anesthesia with Sevoflurane for Postoperative Delirium in Adult Coronary Artery Bypass Grafting Surgery: A Prospective Randomized Single-Blinded Study', Journal of Cardiothoracic and Vascular Anesthesia, Volume 38, Issue 9, (2024), Pages 1932-1940

Varsha AV, Unnikrishnan KP, Babu MSS et al.

Beyond A and B: Exploring a Novel dynamic ECG change in Wellens Syndrome

Rodriguez EA, Espinosa de la Ossa C, Vargas AF et al.

PEEP Titration in Cardiogenic Shock: Impact on Congestion and Hemodynamic Phenotype

Tavazzi G, Fasolino A, Colombo CNJ et al.

Management of Heart Failure With Preserved Ejection Fraction: 2026 ACC Expert Consensus Decision Pathway: A Report of the American College of Cardiology Solution Set Oversight Committee

Kittleson MM, Panjrath GS, Bates K et al.

From Arterial Pressure to Tissue Perfusion: Blood-Pressure Targets after Resuscitated Infarction-Related Cardiac Arrest

Calabrese A, De Backer D, Annoni F

Resuscitative Point-of-Care Ultrasound in Cardiac Arrest: Current Evidence and Clinical Applications

Merren MP, Augustin K, Ripoll JG et al.

Medical Device Safety and Effectiveness: In Theory, There Is No Difference Between Theory and Practice…in Practice, There Is

Vemulapalli S, Wang A

Funding Source and the Online and Academic Impact of Cardiovascular Trials

Zahedi Tajrishi F, Bukhari S, Rashedi S et al.

Cardiac mechanical efficiency in patients with cardiogenic shock

Berg-Hansen K, Hørsdal OK, Wiggers H et al.

Association of Pulmonary Vascular Remodeling With Cardiac Structure and Function, Pulmonary Pressure, and Heart Failure in Late Life: The Atherosclerosis Risk in Communities (ARIC) Study

Dewanjee A, Lamberson V, Yang Y et al.

Effects of a "Food Is Medicine" Intervention on Glucose Control Among Medicaid-Insured Patients With Type 2 Diabetes: A Randomized Controlled Trial

Nau C, Wu JHY, Han B et al.

Ethics of Navigating Organ Scarcity in Heart Transplantation

DeFilippis EM, Kittleson MM

Diagnostic Approach to Cardiac Sarcoidosis

Lehtonen J, Birnie DH

Rapid Ultraoxygenated Recovery Without Preimplant Reanimation Using Older Donation After Circulatory Death Heart Donors

Williams AM, Wang CC, McGann KC et al.

Cracking the Code of Cardiac ATP-Dependent Citrate Lyase With Wet and Dry Tools

Walker MA, Tian R

Cold Oxygenated Rapid Recovery in Heart Donation After Circulatory Death

Bashian EJ, O'Shea TF, Campbell DN et al.

From Discovery to Impact in the Circulation Life Cycle

Khan SS

Stent-Free PCI: Have We Found the SELUTION?

Fadel RA, Aronow HD

Does Characterization of Phenotypic Heterogeneity Provide Mechanistic Insights or Influence the Response to Treatment? Experience in Positive and Neutral Trials in Patients With Heart Failure and a Preserved Ejection Fraction

Packer M, Schiattarella GG, Petrie MC et al.

Loss of ATP-Dependent Citrate Lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling

Liu S, Gammon ST, Tan L et al.

Sirolimus-Eluting Balloon With Provisional Stenting Versus Systematic Drug-Eluting Stent Implantation to Treat De Novo Coronary Lesions: A Randomized, Open-Label, Noninferiority Trial

Spaulding C, Krackhardt F, Bogaerts K et al.

Incremental Prognostic Value of Subendocardial Myocardial Flow Reserve in Patients With Normal Perfusion

Lopez DM, Brown JM, Divakaran S et al.

Ethical Considerations for Heart Organ Allocation: Current Landscape and Future Policy Guidance: A Scientific Statement From the American Heart Association

Khazanie P, Drazner MH, Breathett K et al.

Comparative Efficacy of Transfusion Strategies in Women and Men With Myocardial Infarction and Anemia: Prespecified Secondary Findings From the MINT Trial

Abbott JD, Benatar JR, Ballantyne CM et al.

SIRT5 Ameliorates Cardiac Fibrosis via PCK2 Desuccinylation-Mediated Metabolic Reprogramming in Cardiac Fibroblasts

Wu M, Tan J, Zhou W et al.

The Discussion: Where Every Paragraph Has a Job

Krumholz HM

Hypertension at an Inflection Point: Aggressive Targets Meet Novel Mechanisms for Cardiovascular Prevention

Agarwal R

The Ankle-Brachial Index: A Continuum of Risk and Opportunity

Kadian-Dodov D

Blood DNA Methylation Patterns Across Carotid, Coronary, and Peripheral Atherosclerosis: A Comparative Analysis in 2 Prospective Cohorts

Ingold M, Müller C, Krolevets M et al.

Interleukin-6 as a Biomarker and Treatment Target for Atherosclerotic Disease

Ridker PM

Exposome Fingerprints in Atherosclerosis: DNA Methylation on Stage

Costantino S, Mongelli A, Ruschitzka F et al.

The Expanding Oral Options for LDL Cholesterol Management: Ain't No Cholesterol High Enough, Ain't No Target Low Enough!

Brunham LR, Shapiro MD, Nambi V

Implications of Modest Reductions in ABI Measurements for Risk of Major Adverse Limb Events Among 223,350 Veterans

Aday AW, Eden SK, Kundu S et al.

The Prognostic Value of Serum Interleukin-6 Concentrations for 9 Cardiovascular and Mortality Outcomes: The Cross Cohort Collaboration (CCC)

Yao Z, Dardari ZA, LaMonte MJ et al.

Cardiovascular Risk Prediction Across the Spectrum of Measured Physical Activity

Petek BJ, Ajufo E, Churchill TW et al.

Hypertensive Disorders of Pregnancy in the United States, 2016-2024

Lam EL, Khan SS, Shah NS

Single-Pill Combination Therapy for Hypertension: Persistent Underuse in the United States, 2015-2025

Choi K, Kim C, Spatz ES et al.

Secondary Prevention After Myocardial Infarction in the United States

Chiu N, Libby P, Gong J et al.

From Insight to Infrastructure: Managing Cardiorespiratory Fitness

Alter DA

Midlife Cardiorespiratory Fitness and Healthy Aging: An Observational Cohort Study

Meernik C, Leonard D, Shuval K et al.

Oral PCSK9 Inhibitor Enlicitide Versus Oral Nonstatin Therapies: A Phase 3 Randomized Clinical Trial

Catapano AL, Mikhailova E, Navar AM et al.

Masters Athletes With Abnormal Cardiovascular Findings: A Clinical Consensus Statement of the European Association of Preventive Cardiology of the ESC and the American College of Cardiology

Eijsvogels TMH, Kim JH, Aengevaeren VL et al.

Caffeine and Cardiovascular Disease: A Scientific Statement From the American Heart Association

Marcus GM, Hu FB, van Dam RM et al.

Cold Exposure, Sunlight, and Particulate Matter in Acute Heart Failure: Signals and Uncertainties

Münzel T, Kuntic M, Daiber A

A local complication-prevention pathway for Impella-supported cardiogenic shock: a single-center experience

Correction to: 2026 AHA/ACC/ACCP/ACEP/CHEST/SCAI/ SHM/SIR/SVM/SVN Guideline for the Evaluation and Management of Acute Pulmonary Embolism in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Creager MA, Barnes GD, Giri J et al.

Transforming Pulmonary Arterial Hypertension: Key Milestones and Future Perspectives

Humbert M, Zeder K, Kovacs G et al.

Reversible ECG Changes in a Rare Case of Shock

Fragkoulis Y, Karampinos KI, Karabinos I

The limits of precision in acute cardiovascular care

Vranckx P, Morrow D, van Diepen S et al.

Answer: Imaging findings of an unexpected thoracic mass in a patient with prior valve repair

Santos-Jorge C, Carvalho RA, Brito J et al.

Question: Imaging findings of an unexpected thoracic mass in a patient with prior valve repair

Santos-Jorge C, Carvalho RA, Brito J et al.

Inflammation and endothelium after cardiac arrest: a complex relationship

Benghanem S, Bois A, Cariou A

Cardiopulmonary interactions during positive pressure ventilation: a clinico-physiological framework

Alviar CL, Tavazzi G

Diagnostic validation of a novel high-sensitivity cardiac troponin T assay

Völschow B, Strauß B, Sörensen NA et al.

Cost-effectiveness of extracorporeal CPR for out-of-hospital cardiac arrest: a trial-based Markov model with a lifetime horizon

van de Koolwijk AF, Gabrio A, Delnoij TSR et al.

Pharmacodynamic effects of cangrelor in patients with or without STEMI undergoing percutaneous coronary intervention: insights from the POMPEII study

Gargiulo G, Narciso V, Forzano I et al.

Impact of switching high-sensitivity cardiac troponin assays on risk stratification in suspected acute coronary syndrome

Li Z, Boeddinghaus J, Bularga A et al.

Cardiac myosin-binding protein C in ST-elevation myocardial infarction

Rajakulasingam R, Alaour B, McGrath S et al.

Managing bleeds on anticoagulant therapy: a practical guide for clinicians

Galli M, Simeone B, Ten Berg J et al.