The week’s most important critical care research.

Correction to: 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Blumenthal RS, Morris PB, Gaudino M et al.

Partnerships That Leverage Existing Community Strengths Are Key to Improving Cardiovascular Health

Powell-Wiley TM

Foam Cells Beyond the Intima: Adventitial Macrophage Lipid Loading in Transplant Arteriosclerosis

Monaco C, Lutgens E

Response by Jiang and Zhang to Letter Regarding Article, "HELZ2 Regulates Apob mRNA Stability to Modulate Fatty Liver Disease and Atherosclerosis"

Jiang Y, Zhang Z

Redefining Severe Aortic Stenosis in Symptomatic Patients: The Weakness of Using Simple Cutoffs

Carabello B, Nishimura R

Guideline-Recommended Follow-Up for Moderate Aortic Stenosis in the United States

Kassab J, Rizvi MA, Pandey A et al.

Letter by Xiong et al Regarding Article, "HELZ2 Regulates Apob mRNA Stability to Modulate Fatty Liver Disease and Atherosclerosis"

Xiong B, Wu Q, Qu G

Letter by Huntzinger and Séraphin Regarding Article, "HELZ2 Regulates Apob mRNA Stability to Modulate Fatty Liver Disease and Atherosclerosis"

Huntzinger E, Séraphin B

Impaired Glycolysis Leads to Defective Efferocytosis and Impaired Plaque Resolution in Tet2 Clonal Hematopoiesis

Yalcinkaya M, Hsu CC, Li L et al.

Macrotroponin Complexes and Risk of Cardiovascular Events

de Bakker M, Thurston AJF, Hammarsten O et al.

Arrhythmic Risk Stratification According to LGE Corridors and Genetics in Nonischemic Dilated Cardiomyopathy

Ramos-López N, Mora-Ayestarán N, Ochoa JP et al.

Infective Endocarditis: Diagnosis, Antibiotic Therapy, and Management: A Scientific Statement From the American Heart Association

DeSimone DC, Marks L, Dayer MJ et al.

An Updated Evidence Assessment of the Genetic Causes of Dilated Cardiomyopathy

Jordan E, Grover P, Parker P et al.

HNRNPK Lactylation Amplifies Inflammation and Exacerbates Myocardial Ischemia/Reperfusion Injury by Regulating Jag2 Splicing

Chen S, Shen S, Su W et al.

Overcoming Intrinsic Barriers in Myofibroblasts Permits Efficient Cardiac Reprogramming After Infarction

Wu J, Yang C, Wu D et al.

YAP Promotes Microtubule Growth to Facilitate Sarcomere Disassembly in Adult Cardiomyocytes

Zhang F, Cusick JK, Liang J et al.

Opportunistic Screening for Chagas Disease Using an Artificial Intelligence-Enabled ECG: Prospective Evaluation of Feasibility and Diagnostic Accuracy

Ribeiro ALP, Cardoso CS, Taconeli CA et al.

Surviving Pediatric Cardiogenic Shock: Clinical Approach, Improving Outcomes, and Future Directions: A Scientific Statement From the American Heart Association

Puri K, Allen K, Jentzer J et al.

COL1A1-Enhanced CD44/SLC7A11 Interaction and Cystine Uptake Result in CD34(+) Foam-Like Macrophage Accumulation in Transplant Arteriosclerosis

Wu J, He T, Qi M et al.

Methodologic Standards for Follow-Up Extension in Cardiovascular Trials: A Scientific Statement From the American Heart Association

Gaudino M, Sandner S, Bagiella E et al.

REPLY: Heterogeneous Value of a Multicondition Cardiovascular PRS Panel

Patel AP, Natarajan P

Heterogeneous Value of a Multicondition Cardiovascular PRS Panel

Wang Y, Zhu Y, Wang D

Genetic Variation in Hypoplastic Left Heart Syndrome Heart Failure Outcomes: A Layer of Risk to Stressed Myocardium

Wilsbacher LD, Bucholz EM

Genetic Determinants of Early Heart Failure in Hypoplastic Left Heart Syndrome: A Prospective NC-DEFINE Study

Balint BN, Sunthankar SD, Monaco G et al.

Precision Medicine's Next Task: From More Signals to an Integrated View

Krumholz HM

Triangulating Evidence in Proteome-Wide Mendelian Randomization for Cardiovascular Disease: Insights Across Ancestries and Modalities

Yoshiji S, Clarke SL

Cross-Ancestry Proteogenomic Analyses Identified New Therapeutic Insights for Ischemic Heart Disease

Mazidi M, Wright N, Pozarickij A et al.

Expanding the Genetic Architecture of Severe Hypercholesterolemia

Levin MG

Monogenic ALB Variants as Determinants of Severe Hypercholesterolemia: A Population-Based Cohort Study

Berry ASF, Cawley D, Hattenberger A et al.

Polygenic Risk Scores for Cardiovascular Disease: Closing the Gap Between Prediction and Practice

Clark MG, Levin MG

Development and Validation of a Clinical Polygenic Risk Report in U.S.-Based Health Systems for 8 Cardiovascular Conditions

Misra A, Jowell A, Haidermota S et al.

Gene Editing Therapy in Cardiovascular Disease: 2026 ACC Scientific Statement: A Report of the American College of Cardiology

Ambardekar AV, Bhatt A, Hoekstra M et al.

The PROACT Study and Improving Prevention of ASCVD

Sniderman A

Polygenic Risk Based Detection and Treatment of Subclinical Coronary Atherosclerosis in the PROACT Clinical Trials

Abou-Karam R, Kim MS, Jemma Cho SM et al.

Supplemental oxygen in acute heart failure: is less more?

Galluzzo A, Thevathasan T

Phenotyping Right Ventricular Injury in Septic Shock: Toward Precision Echocardiographic and Hemodynamic Assessment

Slobod D, Goffi A

Truncating Tradition in the POET II Trial: Is a shorter course of antibiotics noninferior to standard length therapy in left-sided endocarditis?

Verbrugge FH, van Diepen S

PRAGUE-26 in perspective: convincing early stabilization, but durable benefit remains unproven

Grand J, Morrow DA

Right ventricular–pulmonary arterial uncoupling and venous excess in normotensive pulmonary embolism shock

Clinical Considerations for the Care of the Tactical Athlete With Cardiovascular Abnormalities: A Scientific Statement From the American College of Cardiology and the American Heart Association

Dineen EH, Haigney MC, Levine BD et al.

Electrocardiographic Principles for the Diagnosis of Occlusion Myocardial Infarction

Helseth HC, Mansur P, El-Baba M et al.

Answer: A dangerous beat in the postpartum heart

Esmailian A, Teng LE, Mehta O

Proximity where possible, concentration where needed

Vranckx P, Morrow D, van Diepen S et al.

Influences of socioeconomic and environmental factors on STEMI incidence and related mortality: Insights from the Belgian Environmental Myocardial Infarction Risk (EMIR) Study

De Potter T, Faes C, Motoc A et al.

Complete revascularization according to age in patients with ST-segment elevation myocardial infarction and multivessel disease: 10-year outcome from the DANAMI-3-PRIMULTI trial

Zhou Y, Özbek BT, Marquard JM et al.

From Observation to Anticipation in a Changing Climate: Building a Climate-Cardiovascular Early Warning System

Li T, Sun Q, Liu Y et al.

Cold Spells, Heat Waves, and Nonoptimal Air Temperature and Risk of Heart Failure Hospitalization in Sweden

Ni W, Agewall S, Benson L et al.

Compound Exposure to Extreme Heat and Substantial Landscape Fire-Sourced Air Pollution on Cardiovascular Mortality

Wen B, Wu Y, Lavigne E et al.

Heat Plus Fire: A Compound Hazard Threatening Cardiovascular Health

Chu L

Constituent-Specific PM(2.5) and Cardiovascular Risk: From Mass to Mixture

Hu Y, Meng X, Chen K

Beyond Propensity Matching: Interpreting Outcomes of Surgical Aortic Valve Replacement Versus Transcatheter Aortic Valve Replacement in Patients With Reduced Ejection Fraction

Imamura T

Is Faster Always Better? Ultra-Fast-Track Versus Fast-Track Extubation in Adult Cardiac Surgery: A Comprehensive Meta-analysis With Meta-regression

Santos K, Patel N, Umibe T et al.

Intermittent Bolus versus Continuous Infusion Erector Spinae Catheters for Median Sternotomy Incisions:A Randomized Controlled Trial

Forrest PB, Guerra-Londono CE, Nowak K et al.

Development and Validation of an Integrated Artificial Intelligence-Powered Clinical Decision Support Application for Cardiac Critical Care: Combining Coagulation Management, Blood Gas Analysis, Mechanical Ventilation, Hemodynamic Assessment, and Extracorporeal Membrane Oxygenation

El-Sonbaty AI

Association Between Preoperative Iron Deficiency and Postoperative Outcomes in Children Undergoing Cardiac Surgery

Matisoff AJ, Teehan E, Signorile M et al.

An Insight Into a Potential Antithrombin-Independent Mechanism of Inadequate Heparin Response in Neonates and Infants Undergoing Pediatric Cardiac Surgery: An Exploratory Study

Swangwong S, Sullivan K, Malm E et al.

The Efficacy and Safety of Weighted Blankets to Reduce Agitation After Cardiac Catheterization and Electrophysiology Procedures in Pediatric Patients With Congenital Heart Disease

Zampi JD, Marchetti K, Smith C et al.

Echocardiographic Assessment of the Mitral Annular Dimensions for Annuloplasty Ring Sizing: A Comparative Clinical Study of Two- and Three-Dimensional Ultrasound

Roesslein M, Platz A, Semmelmann A et al.

Combined Observations From Two Tertiary Centers Reveal Critical Limitations in a Filtration-Based Autotransfusion System During Complex Cardiac Surgery

van Vrouwerf E, Filius A, Vermeer H et al.

Perioperative Management of Patients With Durable and Temporary Left Ventricular Assist Devices Undergoing Non-Cardiac Surgery: A Comprehensive Review

Bottiroli M, Ortoleva J, Pisano D et al.