Critical Care Literature, Curated

The week’s most important critical care research.

Twenty-six high-impact journals across critical care, pulmonary, cardiac, anesthesia, and healthcare leadership — NEJM, JAMA, The Lancet, AJRCCM, CCM, CHEST, ICM, Circulation, JACC, BMJ Leader, and more — auto-tagged by the ICCN editorial calendar. Refreshed every six hours.

16 articles in Pulmonary & Mechanical Ventilation

Thorax

Measurement properties of the sit-to-stand test in community-dwelling people with chronic obstructive pulmonary disease: a COSMIN systematic review

Farley, C., Newman, A. N. L., Phillips, S. M., Smith-Turchyn, J., Brooks, D.

Background The sit-to-stand (STS) test can assess physical function in people with chronic obstructive pulmonary disease (COPD); however, there are multiple versions. No study has used current guidelines to assess the measurement…

Thorax

Development and validation of PRECISE-X model: predicting first severe exacerbation in COPD

Sadatsafavi, M., Miravitlles, M., Quint, J. K., Perugini, V., Tavakoli, H., Amegadzie, J. E., Alcazar Navarrete, B., on behalf of the Respiratory Effectiveness Group (REG)-COPD working group, Roche, Soriano, Usmani, Lapperre, Rhee, Harlander, Kaplan

Objectives In patients with chronic obstructive pulmonary disease (COPD), severe exacerbations (ECOPDs) impose significant morbidity and mortality. Current guidelines emphasise using ECOPD history to inform preventive treatments but offer limited guidance for…

Thorax

Similar movements, different messages: are sit-to-stand tests interchangeable in people with COPD?

Mellaerts, P., Troosters, T., Pancera, S.

Capturing functional exercise capacity is important in guiding treatment and assessing the efficacy of interventions for individuals with chronic respiratory conditions.1 Laboratory-based exercise testing, specifically cardiopulmonary exercise testing (CPET), is considered the…

Thorax

Disproportionate impairment in diffusing capacity predicts pulmonary hypertension with an elevated pulmonary vascular resistance in COPD

Balasubramanian, A., Hemnes, A. R., Brittain, E. L., Annis, J., Fawzy, A., Putcha, N., Singh, A., Wise, R. A., Hansel, N. N., Simpson, C., Kolb, T. M., Hassoun, P. M., McCormack, M. C., Mathai, S. C.

Background Current guidelines for the evaluation of chronic obstructive pulmonary disease (COPD) do not recommend screening for pulmonary hypertension (PH), despite the high prevalence and impact on outcomes. A simple screening tool…

Thorax

Disproportionate increase in COPD exacerbation risk for 3 months after discontinuing LAMA or ICS: insights from the FLAME trial

Mathioudakis, A. G., Bate, S., Chatzimavridou-Grigoriadou, V., Sivapalan, P., Jensen, J.-U. S., Bakerly, N. D., Vestbo, J., Singh, D.

Background In real-world chronic obstructive pulmonary disease (COPD) care, poor adherence often leads to treatment discontinuations. Discontinuing inhaled corticosteroids (ICS) can trigger withdrawal effects transiently increasing exacerbation risk; but evidence for long-acting…

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