The week’s most important critical care research.

Reduction in Right Ventricular Afterload With Inhaled Nitric Oxide Predicts Survival in ARDS

Gibson LE, Giammatteo V, Di Fenza R et al.

Validation of a Model Predicting Tracheostomy in Infants with Evolving Severe Bronchopulmonary Dysplasia

Satcher K, Rowe J, Liu C et al.

Acute effects of oxygen supplementation on quadriceps Neuromuscular Fatigue in COPD patients with Chronic Respiratory Failure

Paneroni M, Vitacca M, Simonelli C et al.

Effectiveness of the adjuvanted RSVPreF3 vaccine in preventing major adverse cardiovascular events and severe exacerbations of chronic obstructive pulmonary disease and asthma among US adults aged ≥60 years

Singer D, Steffens A, La EM et al.

Electrical impedance tomography in ARDS: from improved ventilator settings to uncovering a pressure paradigm?

Prone positioning in ARDS

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ECMO Ethics: A Call for Action

Cunningham TV, Dastidar J, Condella A et al.

Minimal important difference of quadriceps maximal voluntary contraction (QMVC) in COPD: a prospective cohort study

Jenkins, T. O., Edwards, G. D., Patel, S., Canavan, J., Kon, S. S. C., Barker, R. E., Jones, S. E., Walsh, J. A., Ingram, K. A., Maddocks, M., Polkey, M. I., Nolan, C. M., Man, W.

Background Quadriceps maximal voluntary contraction (QMVC) reliably measures quadriceps muscle force and predicts mortality in chronic obstructive pulmonary disease (COPD). However, the minimal important difference (MID) of QMVC is not well-established. Aim…

What constitutes meaningful gain in skeletal muscle strength in COPD?

Mills, G., Greening, N. J.

Low muscle mass and strength is a common systemic consequence of chronic obstructive pulmonary disease (COPD) and an important determinant of clinical outcomes.1–3 Quadriceps muscle strength, in particular, predicts transplant-free survival in…

Unraveling lung function trajectories and social determinants of health: the quest continues

Norgbe, S., MacDonald, D.

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, and COPD prevalence is expected to increase for decades to come.1 2 Worldwide, it is estimated that as many…

Journal club

Carter, J.

Rapid results, Lingering questions: PCR in antibiotic stewardship Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) are a significant cause of morbidity and mortality among patients in the intensive care unit (ICU). Early…

Guidelines adherence: from quality indicator to prognostic relevance

Hoyas-Sanchez, C., Romero-Palacios, P. J., Alcazar Navarrete, B.

The treatment of chronic obstructive pulmonary disease (COPD) has been guided for decades by robust clinical practice guidelines (CPGs), such as NICE1 and GesEPOC,2 as well as international recommendations such as GOLD,3…

ARDS 60th anniversary: spontaneous breathing in ARDS

The ARDS, Pneumonia, and Sepsis (APS) Consortium: Rationale, Design, and Feasibility of a National Platform for Phenotyping Critical Illness Syndromes

Self WH, Calfee CS, Brown SM et al.

Advances in ventilator-associated pneumonia: from pathophysiology to precision management

[Comment] Rethinking anticoagulation intensity during extracorporeal membrane oxygenation

Mauro Panigada, Giacomo Grasselli

Extracorporeal membrane oxygenation (ECMO) is an established therapy for refractory respiratory or circulatory failure,1 yet bleeding and thrombotic complications continue to drive much of the residual morbidity and mortality.2 Clinicians have long…

60 years of ARDS and the evolution of extracorporeal lung support – from ECMO to ECCO2R

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Plasma Levels of Soluble ST2 Reflect Extrapulmonary Organ Dysfunction and Predict Outcomes in Acute Respiratory Failure: Beware of Potential Confounders

De Lissnyder N, Oueslati I, Lefèvre A et al.