Critical Care Literature, Curated
The week’s most important critical care research.
Twenty-six high-impact journals across critical care, pulmonary, cardiac, anesthesia, and healthcare leadership — NEJM, JAMA, The Lancet, AJRCCM, CCM, CHEST, ICM, Circulation, JACC, BMJ Leader, and more — auto-tagged by the ICCN editorial calendar. Refreshed every six hours.
16 articles in Pulmonary & Mechanical Ventilation
Definition and prognostic value of response to prone positioning in ARDS: a systematic review and meta-analysis
Background Methods Results Conclusions PROSPERO registration
Measurement properties of the sit-to-stand test in community-dwelling people with chronic obstructive pulmonary disease: a COSMIN systematic review
Background The sit-to-stand (STS) test can assess physical function in people with chronic obstructive pulmonary disease (COPD); however, there are multiple versions. No study has used current guidelines to assess the measurement…
Development and validation of PRECISE-X model: predicting first severe exacerbation in COPD
Objectives In patients with chronic obstructive pulmonary disease (COPD), severe exacerbations (ECOPDs) impose significant morbidity and mortality. Current guidelines emphasise using ECOPD history to inform preventive treatments but offer limited guidance for…
When biomarkers disagree: interpreting FeNO and eosinophils across airway disease
The search for reliable biomarkers of type 2 (T2) inflammation across asthma, chronic obstructive pulmonary disease (COPD) and asthma–COPD overlap (ACO) has been a defining theme of respiratory research over the past…
Predicting severe COPD exacerbations: are we ready for risk-based care?
Exacerbations play a central role in the burden, progression, economic impact and prognosis of chronic obstructive pulmonary disease (COPD).1 Prevention and treatment of these events are important parts of the management of…
Similar movements, different messages: are sit-to-stand tests interchangeable in people with COPD?
Capturing functional exercise capacity is important in guiding treatment and assessing the efficacy of interventions for individuals with chronic respiratory conditions.1 Laboratory-based exercise testing, specifically cardiopulmonary exercise testing (CPET), is considered the…
Disproportionate impairment in diffusing capacity predicts pulmonary hypertension with an elevated pulmonary vascular resistance in COPD
Background Current guidelines for the evaluation of chronic obstructive pulmonary disease (COPD) do not recommend screening for pulmonary hypertension (PH), despite the high prevalence and impact on outcomes. A simple screening tool…
Disproportionate increase in COPD exacerbation risk for 3 months after discontinuing LAMA or ICS: insights from the FLAME trial
Background In real-world chronic obstructive pulmonary disease (COPD) care, poor adherence often leads to treatment discontinuations. Discontinuing inhaled corticosteroids (ICS) can trigger withdrawal effects transiently increasing exacerbation risk; but evidence for long-acting…
Intrapulmonary penetration of ceftolozane/tazobactam and ceftazidime/avibactam administered by continuous infusion in critically ill patients with nosocomial pneumonia: a randomized pharmacokinetic trial
Background Methods Results Conclusions Trial registration
Interpreting reductions in reintubation after extubation: clinical implications and future directions
The emerging role of diaphragm neurostimulation in ARDS
Extracorporeal Membrane Oxygenation for Pneumocystis Pneumonia: Outcomes in Patients From the Extracorporeal Life Support Organization
Extracorporeal Membrane Oxygenation Combined With Esophageal Pressure-Guided Mechanical Ventilation as Salvage Therapies in Postpneumonectomy Acute Respiratory Distress Syndrome
Advancing Telehealth Pulmonary Rehabilitation for COPD: Bridging Current Practices, Individual Experiences, and Future Needs: A Scoping Review
More Mechanical Support, More Problems: Unpacking Bleeding in ECMO
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