Monday Edition

Sepsis & Shock

Every Monday: the literature that shapes the first hour.

Sepsis mortality remains stubbornly high — 25 to 40 percent in many cohorts. What happens in the first 60 minutes shapes the trajectory. Every Monday, ICCN publishes a bedside-ready summary on sepsis recognition, hemodynamic resuscitation, antibiotic strategy, and the new evidence that should change practice.

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What This Track Covers

Topics on the schedule.

Surviving Sepsis Campaign updates
Hour-1 bundle execution
Balanced crystalloids vs. saline
Norepinephrine first-line dosing
Antibiotic stewardship at the bedside
Septic cardiomyopathy & mixed shock
Lactate clearance & perfusion targets

Latest From This Track

Recent Monday editions.

Monday · Sepsis & Shock

September 7, 2026

INSPIRE: Precision Immunotherapy Delivers Another Positive Signal in Sepsis

The December 2025 Lancet Regional Health Europe phase IIa trial by Tavoulareas, Giamarellos-Bourboulis, and colleagues at the Hellenic Institute for the Study of Sepsis randomized 60 hospitalized adults with community-acquired…

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Monday · Sepsis & Shock

August 31, 2026

Overall, Corticosteroids Are Associated with 10 Percent Higher 28-Day Mortality in Sepsis. But That Aggregate Number Hides a Heterogeneous Treatment Effect: A 2025 Target Trial Emulation with Machine

The May 2025 Nature Communications paper from the Weill Cornell Medicine, University of Florida, Indiana University, and New York-Presbyterian consortium (Rajendran, Xu, Pan, Schenck, Wang, and colleagues) applied target trial…

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Monday · Sepsis & Shock

August 24, 2026

The 2026 Surviving Sepsis Campaign Made a New Conditional Recommendation for MAP 60 to 65 mmHg in Adults 65 and Older with Septic Shock. It Did So Because the Japanese OPTPRESS Trial Was Stopped Early

The multicentre pragmatic OPTPRESS trial, published in Intensive Care Medicine in May 2025 by Endo, Yamakawa, and colleagues, enrolled 518 patients aged 65 or older with septic shock across 29…

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A Note from the Founder

Why Mondays matter.

Sepsis is the single most common reason for ICU admission worldwide, and the decisions made in the first hour are the highest-leverage decisions any clinician makes. Mondays bring rigorous, bedside-focused writing on the trials and guideline updates that change that hour.

— Javier Amador-Castaneda, BHS, RRT, FCCM, PNAP

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