Thursday Edition

Research & Evidence Mastery

Every Thursday: reading the literature the way it deserves to be read.

Research literacy is the foundation of bedside practice. The team that can read the literature beats the team that just hears about it. Every Thursday, ICCN publishes a deep-dive on a landmark trial, a methodology primer, or a critical appraisal of the latest publication moving practice.

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What This Track Covers

Topics on the schedule.

Landmark trial deep-dives
Critical appraisal frameworks (CASP, JAMA users’ guides)
Bayesian vs. frequentist reasoning
Subgroup analyses & their misuse
Composite endpoints & effect sizes
Network meta-analyses
Guideline interpretation & GRADE

Latest From This Track

Recent Thursday editions.

Thursday · Research & Evidence Mastery

September 10, 2026

The Interval Was 0.99 to 1.02: What an Informative Null Actually Looks Like

Six weeks ago this channel read a trial whose confidence interval was wider than the outcome it measured, and concluded it could not answer its own question.

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Thursday · Research & Evidence Mastery

September 3, 2026

Six Millimeters of Mercury: The Number We Have Been Using to Pick Induction Agents

A randomized trial found that ketamine produced a higher lowest blood pressure than propofol after induction.

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Thursday · Research & Evidence Mastery

August 27, 2026

Twenty-Eight Days, Then What? A Survival Benefit That Did Not Survive

A randomized trial of plasma exchange in acute-on-chronic liver failure cut 28-day mortality from 63.9 percent to 44.3 percent.

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A Note from the Founder

Why Thursdays matter.

Most clinicians read summaries of summaries. Thursdays at ICCN push deeper: the actual methods, the actual numbers, the actual judgments that separate a practice-changing study from one that should not have changed anything at all.

— Javier Amador-Castaneda, BHS, RRT, FCCM, PNAP

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